NR52 was in two segments in the ACT, travelling just 5 kilometres from the junction with the Monaro Highway and Canberra Avenue at Fyshwick to the NSW-ACT Border at Beard. From the border it passes through several NSW towns including Queanbeyan, then back into the ACT for a few kilometres between Burbong, northeast of Queanbeyan, and the next NSW town of Bungendore.
The entire Canberra Avenue alignment is multi-lane dual carriageway. Canberra Avenue was known during the 1930s as Uriarra Road. 1
The route is the main road from the ACT to the NSW south coast, eventually connecting with the Princes Highway at Batemans Bay. It is one lane each way with occasional overtaking lanes throughout.